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Alkaline phosphatase

An enzyme signal that can come from bone, liver, bile ducts, or other tissues.

What it is

ALP is an enzyme found in several tissues, with higher amounts in liver, bile ducts, and bone.[1]

Why it matters

Bone-related ALP context can appear in high bone turnover or mineralization disorders, but liver and bile sources must be separated.[1]

What it affects

  • Paget disease can involve elevated ALP when bone remodeling is active.[2]
  • Osteomalacia evaluation may include alkaline phosphatase together with vitamin D, calcium, phosphate, PTH, and kidney markers.[3]

Interpretation traps

  • ALP alone cannot identify the source; other tests are often needed.[1]

Related conditions

Paget disease of boneOsteomalacia and rickets