Rank 19,033,000 estimated deaths
Ischaemic heart disease
#1 global cause, WHO GHE 2021
Cardiac blood supply, atherosclerotic vascular context, pressure load, lipids, glucose, kidney function, and metabolic reserve.
Research reference only. BioConst updates and corrects content over time, but it cannot replace clinician-guided diagnosis, treatment, medication, or testing decisions.
179 parameters118 relationships14 systems
Human Parameter Map
Relationship edges are context links. They do not diagnose, rank personal risk, or prove a single root cause.
Population impact
Which parameter contexts deserve attention?
A global population death-count ranking mapped to monitorable contexts. WHO provides the numeric table; newer GBD 2023 research is used as a freshness cross-check.
Global, all ages, both sexes, WHO Global Health Estimates 2021; released in the 2024 GHE update.Ranked by estimated number of deaths for leading underlying causes. Counts are WHO estimates, not case-fatality rates and not personal risk rankings.
Rank 28,722,000 estimated deaths
COVID-19
#2 global cause, WHO GHE 2021
Pandemic-period respiratory infection burden, with oxygenation, respiratory rate, inflammation, age, immune, cardiovascular, metabolic, lung, and kidney context.
Rank 36,973,000 estimated deaths
Stroke / cerebrovascular disease
#3 global cause, WHO GHE 2021
Cerebrovascular events connect vascular load, rhythm context, lipids, glucose, kidney function, and brain reserve.
Rank 43,520,000 estimated deaths
Chronic obstructive pulmonary disease
#4 global cause, WHO GHE 2021
Airflow limitation, gas exchange, oxygenation, lung-function testing, imaging, exacerbation context, and lung reserve.
Rank 52,454,000 estimated deaths
Lower respiratory infections
#5 global cause, WHO GHE 2021
Pneumonia and lower-airway infection context, connecting oxygenation, respiratory rate, inflammatory response, imaging, age, and immune reserve.
Rank 61,857,000 estimated deaths
Trachea, bronchus, and lung cancers
#6 global cause, WHO GHE 2021
Cancer burden concentrated in lung and airway malignancy context, where imaging, tissue diagnosis, molecular markers, and smoking or exposure history matter.
Rank 71,839,000 estimated deaths
Alzheimer disease and other dementias
#7 global cause, WHO GHE 2021
Memory-network failure, cognitive testing, functional decline, amyloid/tau context, vascular context, and neurodegeneration boundaries.
Related parameters
Rank 81,617,000 estimated deaths
Diabetes mellitus
#8 global cause, WHO GHE 2021
Glucose regulation, vascular injury, kidney risk, neuropathy context, body composition, and cardiovascular-kidney-metabolic overlap.
Rank 91,402,000 estimated deaths
Kidney diseases
#9 global cause, WHO GHE 2021
Filtration loss, albumin leakage, creatinine/cystatin C context, blood pressure, diabetes, fluid-electrolyte balance, and replacement-therapy thresholds.
Rank 101,395,000 estimated deaths
Tuberculosis
#10 global cause, WHO GHE 2021
A high-burden infectious disease, often pulmonary, connecting chronic cough context, microbiologic testing, chest imaging, inflammation, nutrition, immune status, and public-health detection.
Bone
Bone conditions, organized by what fails.
A low-friction map of major bone-condition families. Cards link to existing source-backed research until dedicated condition pages are reviewed.
Bone
Bone mass and fracture resistance
Conditions where bone strength, density, quality, or falls make low-trauma fracture more likely.
Low bone mass / osteopeniaLow bone mass / osteopeniaBone density is below the young-adult reference range, but the label alone is not a treatment instruction.Osteoporosis and fragility fractureOsteoporosis and fragility fractureBone loses enough strength that a low-trauma fall or ordinary load can cause a fracture.
Hormone and remodeling disorders
Conditions where bone remodeling speed or hormone signals become the central problem.
Hyperparathyroid bone diseaseHyperparathyroid bone diseaseExcess parathyroid hormone can push bone turnover and bone loss, but calcium and PTH need clinical context.Paget disease of bonePaget disease of boneFocal remodeling becomes excessive and disorganized, producing enlarged but structurally abnormal bone.
Mineralization and kidney-mineral control
Conditions where mineral deposition or kidney-mineral hormone control changes the meaning of bone data.
CKD-MBDCKD-mineral and bone disorder / renal osteodystrophyKidney disease can change phosphate, calcium, PTH, vitamin D metabolism, bone turnover, and calcification context.Osteomalacia and ricketsOsteomalacia and ricketsBone matrix is present, but mineralization is defective; in children this can disturb growing bones.
Structural, systemic & secondary
Inherited, developmental, and structural fragility
Conditions where collagen, osteoclast function, mosaic lesions, or skeletal development alter strength.
FD/MASFibrous dysplasia / skeletal mosaicismFocal fibro-osseous lesions can replace normal bone and marrow, creating pain, deformity, or fracture risk.OIOsteogenesis imperfecta and heritable fragilityInherited fragility often involves collagen biology; fractures cannot be reduced to calcium intake or BMD alone.osteopetrosisOsteopetrosis / high-density brittle boneBone can become dense but brittle when resorption fails; high density is not automatically strong bone.
Tumor, marrow, and systemic bone destruction
Bone involvement from cancer or marrow disease, kept separate from everyday bone-fragility concerns.
Bone tumors and metastatic bone diseaseBone tumors and metastatic bone diseaseCancer can arise in bone or spread to bone; this belongs in a separate oncology-aware context.Myeloma bone diseaseMyeloma bone diseasePlasma-cell disease in marrow can create osteolytic lesions by increasing breakdown and suppressing formation.
Blood supply, infection, and tissue destruction
Conditions where blood flow failure or infection damages living bone tissue.
Brain
Memory and cognition, organized by what fails.
A source-backed map for memory, cognitive aging, MCI, Alzheimer disease, and the factors that can change cognitive function.
Memory and cognitive decline
Alzheimer disease and neurodegeneration
How Alzheimer disease disrupts memory networks, synapses, amyloid, tau, and brain volume over time.
Alzheimer diseaseAlzheimer disease: memory-network failureAlzheimer disease first disrupts memory-related networks such as the entorhinal cortex and hippocampus, then spreads across brain systems.Alzheimer disease: treatment boundariesAlzheimer disease: treatment boundariesCurrent anti-amyloid antibodies can slow progression in some early Alzheimer contexts, but they are not a promise to bring lost memory back.synapse rebuildingCan synapses be rebuilt, and can neurons be backed up?If neurons and network scaffolding remain, some synaptic compensation may be possible; correctness can only be inferred, and neurons cannot be biologically backed up today.Alzheimer root causeWhat is the root cause of Alzheimer disease?Synapse loss is close to the memory problem, but Alzheimer disease is not explained by one root cause.synapse rebuilding AlzheimerIf synaptic connections came back, would that treat Alzheimer disease?Rebuilding the right working memory-network connections would be a core treatment effect, but more synapses alone would not be enough.
Cognitive aging and decline
The boundary between slower recall, mild cognitive impairment, and dementia-level daily-life loss.
Memory systems and forgetting
How experiences become memory, why recall fails, and why forgetting is not one single process.
Modifiable context and treatment boundaries
Modifiable cognition context
Sleep, vascular risk, sensory input, mood, delirium, medicines, and other factors that can change cognition.
Heart
Cardiac function, organized by what fails.
A source-backed map for coronary blood supply, pump reserve, rhythm, valve flow, heart muscle, and pressure load.
Supply, pump, and rhythm
Coronary blood supply and ischemia
Conditions where the heart muscle does not receive enough oxygen-rich blood.
Pump reserve and pressure load
Conditions where the heart cannot pump enough, fill well, or faces sustained pressure load.
Rhythm and electrical control
Conditions where heartbeat timing or conduction becomes the main problem.
Structure and vascular load
Vascular and metabolic load
Blood pressure, cholesterol, vascular disease, and metabolic context that change cardiac risk.
Valves, structure, and heart muscle
Valve flow, chamber shape, and heart-muscle disorders that change cardiac function.
Cardiomyopathy and heart-muscle diseaseCardiomyopathy and heart-muscle diseaseHeart muscle can become thicker, stiffer, enlarged, or weak, changing pump and rhythm stability.Heart valve disease and flow directionHeart valve disease and flow directionValve stenosis or regurgitation changes how blood moves through and out of the heart.
Blood
Blood function, organized by what fails.
A source-backed map for oxygen carrying, iron context, clotting, bleeding, platelets, marrow production, and blood cancers.
Oxygen carrying and clotting balance
Clotting and bleeding balance
Conditions where blood clots too much, too little, or in the wrong context.
Bleeding disorders and clotting-factorBleeding disorders and clotting-factor contextBleeding disorders affect how the body controls clotting through platelets, clotting factors, or acquired disease context.DVTClotting disorders and thrombosisBlood may form clots too often or without injury, creating deep vein, lung, heart, or stroke context.
Iron and blood production context
How iron stores, marrow production, and red-cell size change anemia interpretation.
Red cells and oxygen carrying
Conditions where red blood cells or hemoglobin cannot deliver enough oxygen signal.
Anemia and oxygen-carrying capacityAnemia and oxygen-carrying capacityAnemia means the blood has fewer healthy red cells than needed, so the body receives less oxygen-rich blood.Sickle cell disease and flow blockageSickle cell disease and flow blockageInherited hemoglobin changes can make red cells sickle-shaped, less flexible, and able to block blood flow.
Platelets, marrow, and malignancy context
Blood cancers and marrow context
Malignant blood-forming tissue problems kept separate from routine blood-count interpretation.
Platelets and marrow production
Platelet number, platelet function, and marrow production problems.
Liver
Liver function, organized by what fails.
A source-backed map for liver-cell injury, bile flow, fat context, scarring, and synthetic function.
Cell injury, bile, and synthesis
Bile flow and bilirubin handling
Conditions where bile flow, bilirubin handling, or jaundice context changes interpretation.
Liver-cell injury and enzyme signals
Conditions where liver cells are injured and enzyme patterns enter the clinical context.
Synthetic and metabolic reserve
Conditions where albumin, clotting context, detoxification, or metabolic reserve is the central issue.
Inflammation, fibrosis, and cancer context
Fatty liver and metabolic context
Conditions where fat in the liver is tied to metabolic risk, inflammation, or fibrosis context.
Fibrosis, cirrhosis, and cancer context
Conditions where long-term injury changes liver structure, scarring, portal context, or cancer risk.
Cirrhosis and liver scarringCirrhosis and liver scarringCirrhosis is advanced scarring that changes liver structure and synthetic, portal, and cancer-risk context.HCCLiver cancer and structural contextPrimary liver cancer belongs in a structural and oncology-aware context, not ordinary liver-panel interpretation.
Kidney
Kidney function, organized by what fails.
A source-backed map for filtration, albumin leakage, fluid balance, acute injury, stones, and kidney failure context.
Filtration, albumin, and fluid balance
Fluid, electrolytes, and acid-base context
Conditions where kidney control of water, salts, and blood chemistry affects the clinical picture.
Filtration and waste clearance
Conditions where kidney filtration, creatinine, eGFR, or urea handling becomes central.
Urine protein and glomerular barrier
Conditions where albumin leakage signals kidney barrier damage or microvascular context.
Albuminuria and glomerular barrier leakAlbuminuria and glomerular barrier leakAlbumin in urine can signal kidney barrier damage and needs repeat, context-aware interpretation.diabetic kidney diseaseDiabetic kidney disease and microvascular contextDiabetes can damage kidney blood vessels; albumin and eGFR help frame kidney-risk context.
Acute injury, stones, and failure context
Acute injury and sudden function loss
Conditions where kidney function changes quickly and needs clinical time-course interpretation.
Stones, obstruction, and urine flow
Conditions where crystals or obstruction disrupt urine flow and kidney pressure context.
Lung
Lung function, organized by what fails.
A source-backed map for airflow, gas exchange, infection, scarring, sleep breathing, and pulmonary blood-flow context.
Airflow, gas exchange, and infection
Airflow and airway inflammation
Conditions where airways narrow, inflame, or obstruct airflow.
Infection and lung-tissue inflammation
Conditions where infection fills or inflames air spaces and changes breathing context.
Scarring, sleep breathing, and blood flow
Scarring and restrictive lung context
Conditions where stiff or scarred lung tissue limits breathing and gas transfer.
Sleep breathing and pulmonary blood flow
Conditions where breathing rhythm during sleep or blocked lung blood flow changes oxygen context.
PEPulmonary embolism and lung blood-flow blockagePulmonary embolism is a blood-flow blockage in the lung and belongs in urgent clinical context.Sleep apnea and breathing interruptionSleep apnea and breathing interruptionSleep apnea is repeated breathing pause or shallow breathing during sleep that changes oxygen and sleep context.
Problem
BioConst
BioConst
Aging appears as drifting biological set-points: bone remodeling, lipid regulation, immune repair, follicle cycling, and tissue renewal all become harder to hold. BioConst studies that loss of control as a research problem, not as medical advice.
The work starts with evidence tracking. Each note separates animal work, early human signals, clinical trials, and unsupported claims, with sources attached to every factual data point.
Research discussion only. Not medical advice.
Operating Rule
Receipts before claims.
Every public fact, number, or model baseline is attached to a visible source. Estimates are marked as estimates. Boundaries stay close to the result.
Initial Evidence Tiers4framework to human data
Source Set5linked references
BoundaryNo adviceresearch discussion