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Hippocampus / entorhinal memory network

A memory-related brain network central to forming new memories and often affected early in Alzheimer disease.

What it is

The hippocampus is a medial temporal lobe structure involved in converting short-term memory into longer-term memory.[1]

Why it matters

Alzheimer disease usually damages connections in memory-related regions such as the entorhinal cortex and hippocampus early in the disease course.[2]

What it affects

  • Problems in this network can show up as difficulty forming or retrieving recent memories.[1,2]

Interpretation traps

  • The hippocampus is not the whole memory system; long-term storage and retrieval involve broader cortical and network processes.[3,2]

Related conditions

How memory is stored and lostAlzheimer disease: memory-network failureMild cognitive impairment