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Synaptic plasticity

The ability of neuronal connections to change strength with experience; a core mechanism discussed in memory biology.

What it is

Synaptic plasticity means experience-dependent changes in the strength of connections between neurons.[1,2]

Why it matters

Long-term potentiation in hippocampal synapses is a plausible mechanism for long-lasting memory-related changes, though it is not the whole explanation of human memory.[1]

What it affects

  • In Alzheimer disease, early loss of synaptic connections is a main hallmark of cognitive decline.[3]

Interpretation traps

  • A cellular mechanism does not automatically translate into a public treatment or memory-restoration claim.[1,3]

Related conditions

How memory is stored and lostAlzheimer disease: memory-network failure